Prostate Cancer Treatment Can Raise Dementia Risk

Oct 13, 2016 · 17 comments
James (New Jersey)
This finding brings up the question of whether treatment with testosterone can reduce the risk of cardiovascular disease and dementia. It seems to be a study worth doing.
Kibbitzer (New York, NY)
This news probably explains Rudy Giuliani's support for Donald Trump.
Allison Williams (Richmond, VA)
Something changed my father but no one ever made the connection between the hormone treatment for prostrate cancer and the fact he insisted Katherine Cryer was talking to him from the TV.
Ian MacFarlane (Philadelphia PA)
What a choice, drooling about sex or drooling in the soup.
Counter Measures (Old Borough Park, NY)
When it comes to non aggressive Prostate Cancer (which fortunately it is, in the overwhelming majority of cases!) the cure seems to be far worse than the ailment! (If anyone can really figure out what that actual ailment is?!) But don't tell that to the urologists or drug manufacturers, whose representatives are always the best dressed and washed folks sitting in the Doctor's office! (By the way, great way to get sample pens and well made coffee mugs ,etc.)
AG (Montreal, Canada)
Could the protective effect of testosterone also be a factor in the higher risk of dementia in women than men?
Susan (Piedmont)
“This study is important and urges us toward future research, but I don’t think it should impact clinical practice.”

Why not? Now we have new information but we're going to ignore it?
drsergekuznetsov (Moscow)
Everything is interdependent. Look for right propotions.
A Goldstein (Portland)
Given this newly determined risk of ADT, Mr. Bakalar should consider a follow up article on genetic testing that determines whether ADT will work. This can be important for patients with prostate cancer diagnoses where ADT therapy is part of the treatment pland but where some patients fail to respond because the cancer cells have one or more of these genetic mutations.
Bartolo (Central Virginia)
What dementia reducing treatments might be available for those whose prostate has been yanked?
Clive Deverall AM., Hon D.Litt. (Perth, Australia)
Poor men with cancer of the prostate. Even before a confirmed diagnosis there is a confusing choice as to what their treatment might be. Very early prostate cancer may be unnecessarily or over treated and whether the patient has radiotherapy, surgery, brachytherapy or hormone treatment can depend on the speciality of the Consultant treating the patient. Many patients suffer silently from incontinence &/or impotence. No wonder depression is a factor to be considered.
WastingTime (DC)
"This was a retrospective study and therefore cannot prove cause and effect. "

Then the headline should not read "prostate cancer treatment can raise..."

It should read "prostate cancer treatment associated with..."

BIG DIFFERENCE.

Further, the article says that low testosterone levels are associated with an increase in the chance of cardiovascular disease, a known risk factor for dementia.

Well? Don't leave us in suspense. Was there a higher incidence of cardiovascular disease in the men who were found to have a higher risk of dementia?
Paul Adams (Stony Brook)
More research needed, but the study is clearly important, and it seems likely that drugs that lower testosterone can cause both cardiovascular disease and dementia (though the latter effect may reflect the former, or even the other way round). But the observed correlation could arise merely (but desirably) because the drugs prolong life - we need a double blind trial with drugs the only variable.
Alabaster E. Surprise (Branford CT)
Surprise! Problems with hormonal drug treatments. The less drugs and supplements you take in many many cases the better. They are chemical concoctions created in factories designed to separate you from your money and marketed by soulless corporations. If they have the illusion of being safe and effective take it with a grain of salt. The only entity that may know it does more harm than good is the maker and they have a real good track record of keeping that secret. Use food and lifestyle as medicine. The human body has evolved over millennia and you're going to let scientists with a few years of training mess with your chemistry? Everything you put into your body or on your body can be good, bad or benign. Much is bad and most of the stuff from factories should be seriously suspect. Be mindful.
Paul Adams (Stony Brook)
Your absurd argument would apply equally to clearly life-saving antibiotics or even setting broken bones. Some treatments work well and others less well, and the only rational response is to carefully design and execute large-scale clinical trials based on the best available science. Yes it's expensive but lives are at stake, and if more medical profits were directed to research the 99% would be healthier and happier.
Dan Green (Palm Beach)
Agree. The best book I ever read of todays current practice of medicine, written by two notable physicians, is titled. " Ending Medical Reversal" Meaning, most of what is initially acceptable gets reversed. Main thrust of book is, to get to evidence based treatment by trials, and use of drugs. Not FDA approval in a lab, as backed up only by, this should work, then to market, then into practice. This confusing state of prostate treatment going on leaves one with no basis for a informed decision.
AG (Montreal, Canada)
Millions of people owe their lives to modern medicine, including me.

Sure there is still a lot to learn, but it has already proven its value.